Saturday, March 2, 2013

Info on Alloimmune implantation dysfunction...

I found this great article, that does a good job of explaining exactly what is going on with us...And while I have not seen Braverman, my labs (and history) reflect this to a T, all the way down to the low T regs, the Th1 domination over Th2 etc...Just thought I would share this for those wondering what all of this stuff really means...Of course, this is just a faucet of the many ( Hashi's/PCOS/auto immune stuff) issues against us, but probably the one that will be the hardest to over come..

Alloimmune Implantation Dysfunction
Every human being has two DQ-alpha genes. One is contributed by the father and the other by the mother. In a small percentage of patients undergoing IVF, paternal-maternal DQ-alpha gene similarities occur.In such cases, following repeated exposures to such genetically matching embryos, this will provoke activation of the decidual immune system. In most cases, through the mechanisms described above, this will lead to NK/CTL activation and reproductive failure (i.e.; infertility, and pregnancy loss).We refer to this phenomenon as alloimmune implantation dysfunction.
This is how alloimmune implantation dysfunction happens:Immunogenetically triggered HLA-G signaling by the embryo leads to a reduction in Treg cells, and eventually to a destabilization of NK/CTLs with domination of TH-1 over TH-2 activity. The severity with which this occurs determines whether total implantation failure will occur, or whether there remains enough residual trophoblastic activity to allow the pregnancy to limp along until the nutritional supply can no longer meet the demands of the pregnancy, at which point miscarriage or pregnancy loss occurs.
With paternal-maternal DQ alpha matching, it often takes several pregnancies for natural killer cell activation to build to the point that a woman with alloimmune implantation dysfunction will present with clinical evidence of implantation dysfunction. Sometimes it starts off with one or two pregnancies surviving to the birth of a baby, whereupon NK cell activity later starts to build, leading to one or more subsequent early miscarriages. Eventually the NK cell/CTL activity is so high that subsequent pregnancies can be lost before the woman is even aware that she was pregnant at all. At this point she is often diagnosed with secondary “unexplained” infertility.

( here is the article's link to read in it's entirety if you wish...I am not so thrilled about his view on treatments for people with DQ matching etc...)

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