Skip to main content

Info on Alloimmune implantation dysfunction...

I found this great article, that does a good job of explaining exactly what is going on with us...And while I have not seen Braverman, my labs (and history) reflect this to a T, all the way down to the low T regs, the Th1 domination over Th2 etc...Just thought I would share this for those wondering what all of this stuff really means...Of course, this is just a faucet of the many ( Hashi's/PCOS/auto immune stuff) issues against us, but probably the one that will be the hardest to over come..


Alloimmune Implantation Dysfunction
Every human being has two DQ-alpha genes. One is contributed by the father and the other by the mother. In a small percentage of patients undergoing IVF, paternal-maternal DQ-alpha gene similarities occur.In such cases, following repeated exposures to such genetically matching embryos, this will provoke activation of the decidual immune system. In most cases, through the mechanisms described above, this will lead to NK/CTL activation and reproductive failure (i.e.; infertility, and pregnancy loss).We refer to this phenomenon as alloimmune implantation dysfunction.
This is how alloimmune implantation dysfunction happens:Immunogenetically triggered HLA-G signaling by the embryo leads to a reduction in Treg cells, and eventually to a destabilization of NK/CTLs with domination of TH-1 over TH-2 activity. The severity with which this occurs determines whether total implantation failure will occur, or whether there remains enough residual trophoblastic activity to allow the pregnancy to limp along until the nutritional supply can no longer meet the demands of the pregnancy, at which point miscarriage or pregnancy loss occurs.
With paternal-maternal DQ alpha matching, it often takes several pregnancies for natural killer cell activation to build to the point that a woman with alloimmune implantation dysfunction will present with clinical evidence of implantation dysfunction. Sometimes it starts off with one or two pregnancies surviving to the birth of a baby, whereupon NK cell activity later starts to build, leading to one or more subsequent early miscarriages. Eventually the NK cell/CTL activity is so high that subsequent pregnancies can be lost before the woman is even aware that she was pregnant at all. At this point she is often diagnosed with secondary “unexplained” infertility.

( here is the article's link to read in it's entirety if you wish...I am not so thrilled about his view on treatments for people with DQ matching etc...)

http://haveababy.com/fertility-information/ivf-authority/understanding-immunologic-implantation-dysfunction_16-2/

Comments

Popular posts from this blog

What you should know if you are considering a tubal reversal

Its been 8 years. 8 years since we took a trip to NC to see DR. Montieth in Chapel Hill. I remember being so excited. I had this picture in my head of how it was going to go during, and after it all. For those of you who don't know, I had my tubes tied in 2009, after the birth of my 3rd, directly following a traumatic still birth. It was a decision made out of fear and trauma, not an informed decision. I ended up having adverse health issues (PTLS) after, and was desperate to find a solution. I stumbled upon a private chat room with others also struggling. Several had gone for a reversal, and seemed to feel so MUCH better after. I had already seen my doctor umpteen times, and they offered no solutions, and insinuated it was "in my head".... I saw all of these ladies posting the day OF surgery saying that they felt relief! I was like, "Yes, this is it!!"... So we saved the 6 Grand, and went and did the reversal. I was PUMPED. I started a blog, YouTube video and F

Some statistics on Miscarriage

Miscarriage Statistics Overall miscarriage risk is 17-22%; risk after gestational sac is visible is 12-15% Miscarriage is one of the most frequent problems in human pregnancy. The most widely accepted definition is that proposed by the World Health Organization in 1977. The incidence among clinical pregnancies  (a pregnancy that is confirmed by both high levels of hCG and ultrasound confirmation of a gestational sac)  is about 12-15%, but including early pregnancy losses it is 17-22%. http://www.ncbi.nlm.nih.gov/pubmed/11950476 After heartbeat is detected, risk of miscarriage is 9.4% at 6wks; 4.2% at 7wks; 1.5% at 8wks; 0.5% at 9wks To estimate the risk of miscarriage among asymptomatic women after a prenatal visit between 6 and 11 weeks of gestation where proof of fetal viability of a singleton was obtained by office ultrasonography at the same visit. METHODS: Those recruited were 697 asymptomatic women who attended their first antenatal visit between 6 (+2 days) and 11(+

Trust & New Pajamas

So, a blog comment I got the other day from wonderful woman, and awesome supporter of mine, caused me to pause a bit, and kind of evaluate some things about my faith and relationship with God. Which I truly appreciate, because she was kind and not judgy in her words...And I felt God gently nudge my heart each time I read the comment over... I felt my face start to burn with emotion, as tears welled up in my eyes...And I finally admitted to myself... I do NOT trust God...At least not fully, like I once did... But I desperately WANT to be at that point again....Trusting fully...And filled with peace... I walked into this journey,  to try for one more, 100% SURE , God was calling us/giving us the desire  to have another baby...I/we were, 100% certain we would walk away with a baby in our arms...As a matter of fact, I would have bet my LIFE on it. Now, 3 years later, I am broken, weary, and so utterly soul shattered, that I simply cannot "look" God in the eyes...H