I really, truly loathe methotrexate.... After the second round, I started to experience some nasty side effects...Last night I ended up at the ER...My hands and legs were going numb, my bones ached, and I was having dizzy spells where I would pass out...NOT cool...They ran a ton of tests and all was well, they said it was probably just a bad reaction to the metho...Lovely..Like I needed more crap to deal with...My HCG still was not going down as of last night either...=/ I am so sick of this craziness....